TABLE 4.
Ever use of specific organophosphates1 by self-reported hearing loss cases and controls identified in the Agricultural Health Study
| Case | Control | |||||
|---|---|---|---|---|---|---|
| Exposure | n | % | n | % | OR2 | 95% CI |
| Cumulative lifetime days of chlorpyrifos use | ||||||
| None | 2533 | 55 | 4927 | 57 | 1.0 | referent |
| 1–63 | 677 | 15 | 1270 | 15 | 1.08 | 0.96–1.21 |
| 64–235 | 679 | 15 | 1230 | 14 | 1.13 | 1.01–1.27 |
| >235 | 672 | 15 | 1243 | 14 | 1.15 | 1.02–1.29 |
| Trend | p=0.07 | |||||
| Missing | 365 | 633 | ||||
| Cumulative lifetime days of coumaphos use | ||||||
| None | 4035 | 90 | 7743 | 91 | 1.0 | referent |
| Any | 466 | 10 | 805 | 9 | 1.07 | 0.94–1.22 |
| Missing | 425 | 755 | ||||
| Cumulative lifetime days of DDVP use | ||||||
| None | 3933 | 86 | 7646 | 88 | 1.0 | referent |
| 1–202 | 319 | 7 | 507 | 6 | 1.08 | 0.91–1.25 |
| >202 | 333 | 7 | 493 | 6 | 1.16 | 1.00–1.36 |
| Trend | p=0.06 | |||||
| Missing | 341 | 657 | ||||
| Cumulative lifetime days of diazinon use | ||||||
| None | 3646 | 77 | 7186 | 80 | 1.0 | referent |
| 0.5–54.6 | 372 | 8 | 619 | 7 | 1.23 | 1.06–1.42 |
| 55–161.8 | 344 | 7 | 574 | 6 | 1.13 | 0.97–1.32 |
| >161.8 | 364 | 8 | 590 | 7 | 1.25 | 1.07–1.46 |
| Trend | p=0.01 | |||||
| Missing | 200 | 334 | ||||
| Cumulative lifetime days of fonofos use | ||||||
| None | 3370 | 73 | 6831 | 78 | 1.0 | referent |
| 1–68.25 | 375 | 8 | 658 | 8 | 1.02 | 0.88–1.18 |
| 68.26–242.83 | 431 | 9 | 601 | 7 | 1.30 | 1.13–1.50 |
| >242.83 | 423 | 9 | 612 | 7 | 1.19 | 1.03–1.37 |
| Trend | p=0.04 | |||||
| Missing | 327 | 601 | ||||
| Cumulative lifetime days of malathion use | ||||||
| None | 1423 | 30 | 3258 | 37 | 1.00 | referent |
| 0.88–57.75 | 1027 | 22 | 1992 | 22 | 1.09 | 0.98–1.21 |
| 58–212 | 1116 | 24 | 1825 | 20 | 1.32 | 1.18–1.46 |
| >212 | 1128 | 24 | 1851 | 21 | 1.20 | 1.08–1.34 |
| Trend | p=0.09 | |||||
| Missing | 232 | 377 | ||||
| Cumulative lifetime days of parathion use | ||||||
| None | 4306 | 91 | 8328 | 93 | 1.00 | referent |
| Any | 417 | 9 | 636 | 7 | 1.21 | 1.04–1.40 |
| Missing | 203 | 339 | ||||
| Cumulative lifetime days of phorate use | ||||||
| None | 2998 | 63 | 6444 | 72 | 1.00 | referent |
| 1.5–54.6 | 609 | 13 | 847 | 9 | 1.21 | 1.06–1.37 |
| 54.83–176.4 | 539 | 11 | 874 | 10 | 1.10 | 0.96–1.24 |
| >176.4 | 593 | 13 | 834 | 9 | 1.25 | 1.10–1.41 |
| Trend | p=0.004 | |||||
| Missing | 187 | 304 | ||||
| Cumulative lifetime days of terbufos use | ||||||
| None | 2647 | 58 | 5255 | 61 | 1.00 | referent |
| 1.25–91 | 626 | 14 | 1168 | 13 | 0.96 | 0.86–1.09 |
| 91.2–348.1 | 630 | 14 | 1155 | 13 | 1.00 | 0.89–1.13 |
| >348.1 | 674 | 14 | 1115 | 13 | 1.17 | 1.04–1.31 |
| Trend | p=0.01 | |||||
| Missing | 349 | 610 | ||||
1
Based on intensity-weighted cumulative days of use
2
ORs adjusted for state, age, solvent exposure, noise exposure, and metal exposures