Computer-assisted maps showing the distribution of neurons expressing KiSS-1 mRNA in representative parasagittal sections from a premenopausal (A) and a postmenopausal (B) woman. Each filled circle represents one labeled neuron. Neurons expressing KiSS-1 mRNA were predominantly located in the infundibular nucleus of both groups. A marked increase in the number of neurons expressing KiSS-1 mRNA was observed in the infundibular nucleus of postmenopausal women. The arrow indicates the location of the infundibular nucleus. Abbreviations: ac, anterior commissure; fx, fornix; INF, infundibular nucleus; MB, mammillary body; MPOA, medial preoptic area; oc, optic chiasm; PH, posterior hypothalamus. Scale Bar = 2 mm.
From Rometo et al. [86], reproduced with permission from The Endocrine Society.