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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Heart Rhythm. 2008 Aug 6;5(9):1304–1309. doi: 10.1016/j.hrthm.2008.05.020

Figure 4.

Figure 4

Concentrations of 4-AP that selectively block IKur fail to prevent or terminate atrial fibrillation in “remodeled” atria. Shown are simultaneously recorded ECG and AP traces. A: 25 µM 4-AP fails to terminate persistent AF induced in the presence of acetylcholine (ACh, 0.5 µM). B: 25 µM 4-AP fails to prevent the induction of non-sustained AF by a single premature beat (S1–S2 = 85 ms, which is ERP) in ischemia/reperfusion+isoproterenol AF model (Isch/Rep/Iso). C: An increase of 4-AP concentration to 100 µM prolongs ERP and prevents the initiation of the arrhythmia by premature stimulation (S1–S2 = 110 ms, which is ERP).