FIG. 1.

Frequency distribution plot of change in BMI over the study duration among subjects on conventional (A) and intensive therapy (B)in the DCCT. Open circles and hatched areas represent subjects without a family history of type 2 diabetes; closed symbols and the line graph represent subjects with a family history of type 2 diabetes. The distributions are not different for the conventional therapy—treated groups (ΔBMI 1.2 ± 1.9 kg/m2 for each group [mean ± SD]) (A), but subjects with a family history of type 2 diabetes in the intensive therapy group had significantly greater weight gain than those without a family history of type 2 diabetes (ΔBMI 3.8 ± 2.8 vs. 2.9 ± 3.2 kg/m2 [mean ± SD], family history versus no family history, respectively, P = 0.004) (B).