TABLE 2.
Follow-up results of subjects with and without a family history of type 2 diabetes
| Conventional therapy |
Intensive therapy |
|||||
|---|---|---|---|---|---|---|
| No family history | Family history | P | No family history | Family history | P | |
| n | 532 | 54 | - | 521 | 61 | - |
| BMI (kg/m2) | 25.1 ± 3.1 | 25.4 ± 3.1 | 0.57 | 26.4 ± 4.3 | 27.8 ± 3.9 | 0.002 |
| HbA1c (%) | 9.2 ± 1.5 | 9.3 ± 1.4 | 0.46 | 7.2 ± 1.0 | 7.4 ± 1.3 | 0.21 |
| Insulin dose (units · kg-1 · day-1) | 0.62 ± 0.17 | 0.61 ± 0.17 | 0.20 | 0.66 ± 0.21 | 0.73 ± 0.21 | 0.03 |
| Triglyceride (mmol/l) | 0.96 ± 0.58 (0.03) | 0.98 ± 0.53 (0.18) | 0.23 | 0.86 ± 0.47 (-0.02)* | 1.04 ± 0.64 (0.01) | 0.02 |
| Total cholesterol (mmol/l) | 4.76 ± 0.91 (0.10)† | 4.94 ± 0.93 (0.18) | 0.03 | 4.60 ± 0.78 (-0.01) | 4.81 ± 0.78 (0.13)‡ | <0.05 |
| LDL cholesterol (mmol/l) | 2.97 ± 0.81 (0.14)† | 3.18 ± 0.82 (0.08) | 0.02 | 2.88 ± 0.69 (-0.007) | 3.06 ± 0.67 (0.18)§ | 0.02 |
| HDL cholesterol (mmol/l) | 1.34 ± 0.34 (0.08)‡ | 1.29 ± 0.36 (0.08) | 0.29 | 1.34 ± 0.34 (-0.02) | 1.29 ± 0.31 (0.05) | 0.20 |
| Apolipoprotein B (g/l) | 0.85 ± 0.22 | 0.91 ± 0.24 | 0.01 | 0.82 ± 0.19 | 0.90 ± 0.33 | 0.03 |
| Systolic BP (mmHg) | 116 ± 14 | 116 ± 10 | 0.65 | 116 ± 13 | 116 ± 11 | 0.62 |
| Diastolic BP (mmHg) | 75 ± 9.5 | 74 ± 8.9 | 0.55 | 74 ± 9.3 | 74 ± 8.2 | 0.75 |
| Natural waist circumference (cm) | 82.1 ± 9.4 | 84.8 ± 10.5 | 0.08 | 83.7 ± 10.9 | 87.9 ± 12.4 | 0.01 |
| Natural WHR | 0.82 ± 0.08 | 0.84 ± 0.07 | 0.10 | 0.82 ± 0.09 | 0.84 ± 0.11 | 0.04 |
Data are means ± SD. Data in parentheses represent change from baseline. P represents comparison of no family history versus family history.
*
P = 0.03
†
P < 0.001
‡
P = 0.01
§
P < 0.01 vs. baseline. BP, blood pressure