Table 3.
Clinical/pathological features at initial diagnosis and outcome details of OC patients recurring as ILNR: data from the available literature
| Author | Blanchard et al. [7] | Benedetti Panici et al. [8] | Santillan et al. [9] | Uzan et al. [10] | Current study |
| ILNR | |||||
| - N° of cases | 27 | 19 | 25 | 12 | 32 |
| - % of OC recurrences | n.r. | n.r. | n.r. | n.r. | 10.6 |
| - % of OC | 4.2 | n.r. | n.r. | n.r. | 6.1 |
| Stage III-IV | 67% | 60% | 72% | 50% | 94% |
| RT at first surgery >2 cm | n.r. | <5%a | 8% | 8.3% | 37.5% |
| Poor differentiated | n.r. | 60% | 100% | n.r. | 68% |
| Systematic lymphadenectomy at first surgery | 0 | 0 | 0 | 0 | 0 |
| Complete response after Initial treatment | 59.3% | n.r. | 100% | n.r. | 65.6% |
| Histological diagnosis of ILNR | 63% | 100% | 100% | 100% | 37.5% |
| Cases with CA125 levels | |||||
| >35 U/ml at the time of ILNR | 92% | 60% | 50% | 100% | 93% |
| PFI, months Median (range) | 26 (1–159) | 14 (7–84) | 16 (6–40) | 21 (6–72) | 17.5 (1–130) |
| Site of ILNR | |||||
| -Aortic N° (%) | 15 (55.5%) | 30 (75%)b | 16 (64%) | 7 (58.3%) | 23 (71.9%) b |
| -Pelvic N° (%) | 4 (14.8%) | 10 (25%) | 4 (16%) | 5 (41.7%) | 1 (3.1%) |
| -Other N° (%) | 14 (51.8%) | n.r. | 6 (24%) | 2 (16.7%) | 8 (25.0%) |
| Secondary cytoreduction | 29.6% | 72.5% | 100% | 100% | 37.5% |
| Median follow up duration from ILNR diagnosis (mts) | n.r. | 26 | 19 | 50 | 19.5 |
| Median PRS (mts) | 26 | >60 | 37 | >60 | 37 |
| Median OS (mts) | 68 | n.r. | 61 | 114 | 109 |
| Prognostic factors influencing PRS | None | -Secondary cytoreduction | None | n.r. | -PFI>24 mts -Secondary surgery |
n.r. = not reported
a Residual tumor > 1 cm
b Para-aortic with or without pelvic lymph node involvement