Table 1.
Summary of fatty acid-induced effects on the adipocytic secretion of adiponectin, resistin and monocyte chemoattractant protein-1 (MCP-1)
| FA classification | FA | FA dose (μm) | Adiponectin | Resistin | MCP-1 |
|---|---|---|---|---|---|
| C16 saturated | Stearic acid | 10 | ↑ | ↑ | ↓ |
| Stearic acid | 100 | ↑ | ↑2 | ↑↑12 | |
| C18 saturated | Palmitic acid | 10 | ↑ | ↑2 | ↔ |
| Palmitic acid | 100 | ↑ | ↔ | ↑↑1 | |
| C18 monounsaturated | Oleic acid | 1 | ↑ | ↑ | ↓ |
| Oleic acid | 10 | ↑ | ↑ | ↓↓ | |
| C16 monounsaturated | Palmitoleic acid | 1 | ↑ | ↑12 | ↓↓ |
| Palmitoleic acid | 10 | ↑ | ↔ | ↔ | |
| C18 polyunsaturated | Linoleic acid | 1 | ↑ | ↑ | ↓ |
| Linoleic acid | 10 | ↑ | ↔ | ↔ |
FA = fatty acid, ↔ no change, ↑ up-regulation, ↓ down-regulation; ↑↑ strong up-regulation, ↓↓ strong down-regulation.
1
Effect mediated via nuclear factor-κB
2
effect mediated via Toll-like receptor-4.