Table 1.
Cell population in the lung during infection
| Cell type | Phenotype | Mean number of cells × 105 (SEM × 105) | ||
|---|---|---|---|---|
| Day 0 | Day 3 | Day 6 | ||
| Total cells | Lean | 105 (12·6) | 118 (11·9) | 294 (35·0) |
| Obese | 91·5 (15·4) | *67·2 (8·6) | 188 (32·8) | |
| Alveolar macrophages | Lean | 6·4 (0·69) | 5·9 (0·49) | 13·2 (2·3) |
| Obese | *3·1 (0·96) | *4·4 (0·31) | 7·9 (1·6) | |
| Monocytes/interstitialmacrophages | Lean | 18·8 (3·1) | 44·7 (5·2) | 80·8 (14·9) |
| Obese | 17·8 (2·4) | *18·9 (3·0) | 59·4 (14·1) | |
| Dendritic cells | Lean | 15·6 (2·2) | 25·8 (1·7) | 90·0 (12·3) |
| Obese | 16·0 (2·4) | *11·6 (1·2) | *55·6 (9·3) | |
| CD11b– CD11c– | Lean | 62·0 (7·2) | 41·0 (4·0) | 101 (13·6) |
| Obese | 54·1 (9·7 | 31·4 (3·6) | *59·1 (10·2) | |
Cell populations from total lung were identified by CD11b and CD11c expression (Fig. 1) at various time-points post-infection (p.i.). Data are expressed as mean (standard error of mean (SEM)) of three to six animals per group per time-point.
*
Significantly different from lean mice; P ≤ 0·05.