Figure 5.
Comparable levels of serum total immunoglobulin G (IgG) between activation-induced deaminase (AID) wild-type and heterozygous MRL/lpr mice. Sera were prepared from AID wild-type mice (n= 19) and heterozygotes (n= 18) at 16–18 weeks (n= 19 and n= 20 for 10-week-old AID wild-type and heterozygous MRL/lpr mice, respectively) and tested for total IgG using commercial enzyme-linked immunosorbent assay kits. Error bars represent standard errors. No statistical differences were found between AID wild-type and heterozygous mice for any of the age groups (P> 0·05, Wilcoxon rank sums test). Similar results were obtained for serum levels of IgA (data not shown).