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. Author manuscript; available in PMC: 2009 Feb 1.
Published in final edited form as: Int J Parasitol. 2008 Aug 12;39(3):315–326. doi: 10.1016/j.ijpara.2008.07.007

Fig. 8.

Fig. 8

AF3 triggers the recovery of PF1-inhibited currents. (A) Voltage-activated inward currents records: control; PF1 (1 μM) (red) and; AF3 (1 μM). Note the decrease in amplitude of the Ipeak and the Iss currents after PF1 application and recovery of currents after AF3 application. Recordings were made in calcium-Ringer solution with cesium acetate in recording micropipettes. (B) Ipeak current step–voltage relationship for the experiment shown in (A). Control: Inline graphic PF1 (1 μM): Inline graphic AF3 (1 μM): Inline graphic Postwash: Inline graphic (C) Iss current step–voltage relationship for the experiment shown in (A). Control: Inline graphic PF1 (1 μM): Inline graphic AF3 (1 μM): Inline graphic Post-wash: Inline graphic (D) Inhibition of the Ipeak current after PF1 and recovery after AF3 application (paired t-test, n = 5, **P ≤ 0.01, *P ≤ 0.05). (E) Inhibition of the Iss current after PF1 application and recovery after AF3 application. Note that AF3 potentiated the Iss current (paired t-test, n = 5, **P ≤ 0.01, *P ≤ 0.05).