Table 1. Calculated qMT and DTI parameters for mice optic nerve.

Calculated qMT and DTI parameters for respective ROIs (Each pixel was fitted individually and these results were then averaged over the ROIs). We chose the whole optic nerve (excluding boundary pixels), which contains 12-20 pixels, as the ROI for each injured and uninjured optic nerve. The positioning of those ROIs were based on the relative anisotropy maps which have the most contrast between optic nerve and surrounding tissues, as shown in Figure 1. The p value (for the comparison of left injured against right uninjured) represents the statistically significant difference calculated by t-test.

			left (injured)	Right (uninjured)	p value
qMT	pool size ratio	control	0.102±0.011	0.099±0.014	0.70
		shiverer	0.069±0.004	0.076±0.007	0.07
	fast rate ( s-1)	control	24±8	24±9	0.94
		shiverer	25±3	27±10	0.82
	slow rate ( s-1)	control	0.92±0.09	0.92±0.08	0.90
		shiverer	0.89±0.04	0.87±0.05	0.50
DTI	radial diffusivity ( μm2 / ms )	control	0.17±0.03	0.17±0.03	0.90
		shiverer	0.22±0.02	0.22±0.04	0.84
	axial diffusivity ( μm2 / ms )	control	0.49±0.09	0.67±0.07	0.006
		shiverer	0.53±0.05	0.73±0.06	0.0002
	relative anisotropy	control	0.53±0.06	0.67±0.04	0.0011
		shiverer	0.49±0.04	0.63±0.05	0.0005