Table 2. Allele frequency and genotype analysis of CTLA-4 −318 and +49 polymorphisms in patients with AAU and healthy controls.
| AAU patients (n=140) | Controls (n=92) | p value | |
|---|---|---|---|
|
CTLA-4 −318 | |||
| C |
0.91 |
0.95 |
0.14 |
| T |
0.09 |
0.05 |
|
| Genotype | |||
| CC |
123 |
83 |
ns |
| CT |
15 |
9 |
|
| TT |
2 |
0 |
|
|
CTLA-4 +49 | |||
| A |
0.58 |
0.64 |
0.24 |
| G |
0.42 |
0.36 |
|
| Genotype | |||
| AA |
49 |
38 |
ns |
| AG |
64 |
41 |
|
| GG |
27 |
13 |
|
|
CTLA-4 Haplotype | |||
| CA |
138 |
108 |
0.06 |
| CG |
117 |
67 |
0.29 |
| TA |
25 |
9 |
0.15 |
| TT | 0 | 0 | - |
There was no significant differences in haplotype or genotype frequency between patients with AAU and healthy controls. ns=not significant.