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. 2009 Feb 5;4(2):e4341. doi: 10.1371/journal.pone.0004341

Figure 6. Targeting strategy for the conditional inactivation of the Drapc1 gene.

Figure 6

(A) Restriction map of the mouse Drapc1 locus, the targeting vector and the targeted allele. Relevant restriction sites: A, AvrII; B, BamHI; N, NsiI. Vertical dotted lines highlight homologous regions. (B) Southern analysis of genomic DNA from ES cells (BamHI digestion), with the 5′ probe illustrating the 6.4 kb wild-type (wt) and 4.9 kb targeted (cond) alleles. (C) Southern analysis of genomic DNA from ES cells (AvrII digestion), with the 3′ probe illustrating the 14.2 kb wild type (wt) and 6.4 kb targeted (cond) alleles.