Figure 2.
Progesterone concentration, LTP, LTD, and IPSC recordings. (A) Vehicle and P4 at different concentrations (10−9, 10−8, 10−7, and 10−6 M) were compared with fEPSP values during the baseline synaptic transmission (BST), LTP, and LTD periods. At the highest concentration tested, P4 attenuated BST and LTP, but had no effect on LTD. (B) Using intracellular recordings of inhibitory post-synaptic currents (IPSCs), P4 at 10−6 M increased GABAA receptor-mediated current in two of five recorded cells. Representative current traces recorded before and during P4 application at 10−6 M.