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High leucovorin supplementation prevents activation of MAPK pathways in response to FDH. A. Levels of phosphorylated JNK, ERK, c-Jun and Elk-1 in PC-3 cells in the presence and in the absence of leucovorin (LU) supplementation. B. Levels of phosphorylated JNK and Ser6 p53 in A549 cells in the presence and in the absence of leucovorin (LU) supplementation. Expression of FDH in Tet-On A549/FDH cells was induced by addition of 2.5 μg/ml doxycycline.
