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. 2008 Nov 29;37(2):368–381. doi: 10.1093/nar/gkn918

Figure 1.

Figure 1.

Primary and secondary structure analysis of the CChMVd (+) and (–) hammerheads. (A) Wild-type hammerheads and secondary structure of a CChMVd (–) hammerhead with a shortened but functional domain II as revealed by the similar self-cleavage rate-constants. Active site nucleotides highly or strictly conserved in most natural hammerheads are indicated with a black background. (B) Secondary structures of the I– and II– (right), and I+ and II+ (left) domains studied by NMR spectroscopy. Additional nucleotides are shown in green. (C) Natural sequence variability found in CChMVd (+) and (–) hammerheads, indicated within boxes with gray background. Variants labeled with subscript 1 have only been detected once in the databases. In (A), (B) and (C), the extrahelical U of domain I is shown in red.