Table 1.
qMT parameters derived from a two-pool model fit to the acquired MTw z-spectra for cervical spinal cord white and gray matter. White matter ROIs were taken from lateral and dorsal columns and gray matter taken from lateral/dorsal horn; both at the level of C2. R is the rate of MT exchange (in Hz), Mob is the fraction of semi-solid spins, and T2b is the transverse relaxation time of the semisolid spins.
| R (Hz) | Mob (%) | T2b (ms) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Lateral | Dorsal | GM | Lateral | Dorsal | GM | Lateral | Dorsal | GM | |
| Control | 52 ± 8 | 63 ± 14 | 67 ± 12 | 13 ± 2 | 15 ± 2 | 8 ± 2 | 9 ± 2 | 8 ± 1 | 9 ± 2 |
| X-ALD Female | |||||||||
| ALD1 | 44 ± 21 | 76 ± 16 | 67 ± 14 | 13 ± 3 | 13 ± 2 | 5 ± 1 | 7 ± 1 | 10 ± 1 | 16 ± 2 |
| ALD2 | 60 ± 30 | 66 ± 19 | 62 ± 27 | 16 ± 5 | 11 ± 6 | 6 ± 1 | 5 ± 3 | 17 ± 10 | 12 ± 8 |
| ALD3 | 60 ± 20 | 67 ± 12 | 42 ± 29 | 13 ± 4 | 7 ± 1 | 7 ± 2 | 8 ± 4 | 14 ± 2 | 9 ± 1 |
| ALD4 | 56 ± 20 | 19 ± 8 | 39 ± 8 | 7 ± 1 | 15 ± 2 | 7 ± 1 | 11 ± 3 | 4 ± 1 | 10 ± 2 |
| ALD5 | 72 ± 22 | 53 ± 29 | 54 ± 23 | 10 ± 1 | 14 ± 3 | 9 ± 1 | 8 ± 1 | 5 ± 1 | 8 ± 1 |
| Mean | 58 ± 13 | 56 ± 22 | 53 ± 12 | 12 ± 4 | 12 ± 3 | 7 ± 1 | 8 ± 3 | 10 ± 6 | 11 ± 3 |
| AMN Male | |||||||||
| AMN1 | 54 ± 40 | 60 ± 29 | 71 ± 8 | 11 ± 1 | 9 ± 1 | 5 ± 1 | 11 ± 2 | 5 ± 1 | 12 ± 2 |
| AMN2 | 53 ± 25 | 53 ± 30 | 59 ± 27 | 11 ± 2 | 14 ± 3 | 7 ± 1 | 6 ± 1 | 4 ± 1 | 8 ± 1 |
| AMN3 | 73 ± 19 | 66 ± 20 | 71 ± 42 | 11 ± 2 | 6 ± 1 | 6 ± 1 | 9 ± 1 | 9 ± 1 | 13 ± 1 |
| AMN4 | 61 ± 34 | 56 ± 21 | 39 ± 21 | 13 ± 2 | 8 ± 1 | 15 ± 5 | 10 ± 2 | 9 ± 1 | 4 ± 2 |
| Mean | 61 ± 12 | 59 ± 6 | 60 ± 15 | 11 ± 2 | 9 ± 3 | 8 ± 5 | 9 ± 2 | 7 ± 3 | 9 ± 4 |