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. Author manuscript; available in PMC: 2009 Sep 26.
Published in final edited form as: Circ Res. 2008 Aug 21;103(7):702–709. doi: 10.1161/CIRCRESAHA.108.175489

Figure 4.

Figure 4

Pbx1+/−2−/− mice have bicuspid semilunar valves. A and B, Casting of the aortic valves in newborn wild-type (A) and Pbx1+/−2−/− (B) mice. Asc. Ao indicates ascending aorta; LCA, left coronary artery; RCA, right coronary artery; LCC, left coronary cusp; RCC, right coronary cusp; NCC, noncoronary cusp. C and D, Histological sections show the tricuspid aortic valve in a wild-type (C) and bicuspid aortic valve in a Pbx1+/−2−/− embryo (D) at E14.5. RV indicates right ventricle. E and F, Histological sections show a tricuspid pulmonic valve in a newborn wild-type (E) mouse vs a bicuspid aortic valve in a newborn Pbx1+/−2−/− mouse (F). MPA indicates main pulmonary artery. G, Schematic representation of the trileaflet aortic and pulmonic valves. AV indicates aortic valve; PV, pulmonic valve; AC, anterior cusp; LPC, left posterior cusp; RPC, right posterior cusp. H, Schematic representation of the bicuspid aortic and pulmonic valves in Pbx1+/−2−/− mice. The noncoronary cusp (NCC) of the aortic valve and the anterior cusp (AC) of the pulmonic valve fail to develop.