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Meis1-null embryos display an overriding aorta and ventricular septal defect. A through D, Hematoxylin/eosin-stained sections from littermate E14.5 wild-type and Meis1−/− embryos. The aorta connects to the left ventricular OFT (LVOT) (A) but not the RVOT (C) in a wild-type embryo. In Meis1−/− embryos, the aorta connects to both the left ventricular OFT (B) and RVOT (D). AV indicates aortic valve; VSD, ventricular septal defect.
