Table.
Genotype | Lethality | Cardiac Phenotype |
---|---|---|
Pbx3−/− | Neonatal | None |
Pbx2−/− | Increased | None |
Pbx2−/−;Pbx3+/− | Increased | None |
Pbx2−/−;Pbx3−/− | Embryonic | None |
Pbx1+/− | None | None |
Pbx1+/−;Pbx3+/− | Neonatal | None |
Pbx1+/−;Pbx2+/− | Increased | None |
Pbx1+/−;Pbx2+/−;Pbx3+/− | Neonatal | Bicuspid aortic valve |
Pbx1+/−;Pbx2−/− | Neonatal | Overriding aorta; VSD; bicuspid aortic and pulmonic valves |
Pbx1+/−;Pbx2−/−;Pbx3+/− | Embryonic | Tetralogy of Fallot (RVOT obstruction, VSD, right ventricular hypertrophy, overriding aorta) |
Pbx1−/− | E15 to E16 | Truncus arteriosus originating from the right ventricle; VSD |
VSD indicates ventricular septal defect.