TABLE 5.
HAPLOTYPE ALLELE FREQUENCIES IN CONTROL SUBJECTS AND PATIENTS WITH INFECTION-INDUCED ALI
| ARDS Network Population
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Block 2 Haplotype* | Case Control
|
Ventilator-free Days
|
28-Day Mortality
|
||||||
| Case | Control | P Value | ≤14 | >14 | P Value | Dead | Alive | P Value | |
| G-C-T-C | 0.625 | 0.616 | NS | 0.619 | 0.629 | NS | 0.627 | 0.623 | NS |
| C-C-C-T | 0.175 | 0.210 | NS | 0.195 | 0.159 | NS | 0.167 | 0.177 | NS |
| C-T-C-T | 0.142 | 0.066 | 0.02 | 0.167 | 0.125 | NS | 0.190 | 0.126 | 0.09 |
| G-C-C-T | 0.034 | 0.037 | NS | 0.009 | 0.061 | 0.01 | 0.008 | 0.050 | 0.02 |
Definition of abbreviations: ARDS = acute respiratory distress syndrome; ALI = acute lung injury.
*
Extracellular superoxide dismutase block 2 haplotype consists of 4691-5360-5955-5982. Logistic regression models, in which weights or posterior probabilities are assigned to haplotypes, were used to test haplotypes as independent variables (38).