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. 2008 Oct 17;179(2):138–150. doi: 10.1164/rccm.200804-535OC

Figure 4.

Figure 4.

Nrf2 deficiency augmented lung mucous cell metaplasia after respiratory syncytial virus (RSV) infection. (A) Representative light photomicrographs (n = 3–5/group) visualize AB/PAS-stained lung sections for intraepithelial mucosubstances, a marker of mucous cell metaplasia, in mice after RSV (5 days). Arrows indicate mucosubstances stored in the bronchial epithelium. AV = alveoli; EP = epithelium; BR = bronchi or bronchiole. Bars indicate 100 μm. (B) Morphometric measurement of volume density (Vs) of AB/PAS-positive mucosubstances in bronchial epithelium. Data presented as mean ± SEM (n = 3–5/group). *Significantly different from genotype-matched vehicle mice (P < 0.05). +Significantly different from exposure-matched Nrf2+/+ mice (P < 0.05). (C) Muc5ac protein level in lung homogenates determined by Western blot analysis. Representative digitized images are shown from multiple analyses.