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. 2008 Oct 17;179(2):138–150. doi: 10.1164/rccm.200804-535OC

Figure 5.

Figure 5.

Nrf2 deficiency enhanced respiratory syncytial virus (RSV)-induced nasal airway injury. Representative light photomicrographs (n = 3–5/group) of AB/PAS staining depicted acidic and neutral mucosubstances in Nrf2+/+ and Nrf2−/− mice after vehicle (A) and RSV infection (B, 3 days). RSV caused greater mucus hypersecretion to air space and focal mucous cell hyperplasia in mucosal epithelium of mid-septum as well as mild mucous cell metaplasia in the epithelium lining maxilloturbinates in Nrf2−/− than in Nrf2+/+ mice. Higher magnification of midseptum stained with H&E elucidated respiratory epithelial lesions manifest by abnormal epithelial differentiation and goblet cell proliferation in Nrf2−/− mice infected with RSV. Arrows indicate AB/PAS-stained intraepithelial or secreted mucosubstances. Arrowheads indicate focal injury sites. C = cartilage; E = epithelium; MT = maxilloturbinate; S = septum. Bars indicate 100 μm.