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. Author manuscript; available in PMC: 2009 Jan 30.
Published in final edited form as: Synlett. 2006 Nov 13;2007(4):571–582. doi: 10.1002/ejoc.200600767

Table 3.

Optimization studies

graphic file with name nihms-87961-t0045.jpg
Ligand Temp. Ratio 32:33 Yielda,b
Dpe-phos 110 °C 3:1 64%
Dppe 110 °C >20:1 100%
Dppb 60 °C >20:1 100% (94%)
a

Conditions: 1.0 equiv amine, 1.1. equiv 2-bromonaphthalene, 1.2 equiv NaOtBu, 1 mol % Pd2(dba)3, 2 mol % ligand, toluene (0.25 M), 60-110 °C.

b

Yields refer to GC yields measured against an internal standard. Yields in parentheses are isolated yields.