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. 2009 Feb 1;20(3):882–890. doi: 10.1091/mbc.E08-07-0731

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© 2009 by The American Society for Cell Biology

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Figure 7. — The increased nuclear localization of β-catenin and increased c-Myc expression in Smad4 mutant epidermis. (A–D) The immunofluorescence of active-β-catenin in the HFs of the control (A and C) and Smad4 mutant mice (B and D) at P42. (E and F) The immunofluorescence of α6-integrin and CD34 in HFs showed that α6-integrin was down-regulated in SC niche of Smad4 mutants at P42. (G) The expression of total β-catenin, active-β-catenin, PTEN, p-Akt, p-GSK-3β, c-Myc, and β1-integrin in epidermis of P42 Smad4 mutant and control mice were detected by Western blot analyses. Bar, (A and B) 35 μm; (C and D) 15 μm; (E and F) 25 μm.