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Social isolation impairs prepulse inhibition in rats with a sucrose self-administration history. (A) Baseline startle responses to an auditory stimulus were not significantly different between group- and isolation-housed animals following five weeks of operant self-administration experience. (B) Attenuation of the startle response by a pre-stimulus auditory cue was significantly less in isolated animals compared to group-housed individuals. * – P<0.05, t-test
