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Tumorigenic phenotypes in Rb-/- versus Rb-/-;E2f4-/- chimeric mice.
| Rb-/- %, N animals | Rb-/-;E2f4-/- %; N animals | |
|---|---|---|
| Average chimerism | 62%; 13 | 28%; 21 |
| Pituitary tumors | 69%; 13 | 38%; 21 |
| Thyroid tumors | 31%; 13 | 16%; 19 |
| Adrenal gland lesions | 58%; 12 | 67%; 18 |
| Pulmonary neuroendocrine cell hyperplasia |
77%; 13 | 20%; 20 |
| Neuroendocrine ganglionic neoplasms |
0%; 12 | 30%; 20 |
| Uroepithelium lesions | 0%; 12 | 15%; 20 |
