Table 1.
Recent clinical trials (top) and pilot studies (bottom) testing in vivo optical imaging techniques for early detection of cervical cancer and its precursors
| Type of Detection | N = # of Patients in Analysis | Sensitivity (%) / Specificity (%) | Type of Study | |
|---|---|---|---|---|
| Major Trials | Colposcopy6 | 5378 | 85/69 | Prospective |
| VIA90 | 2148 | 77/64 | Prospective | |
| VIA91 | 2817 | 67/83* | Prospective | |
| VIA92 | 1997 | 71/74* | Prospective | |
| VIA13 | 2575 | 70/79 | Prospective | |
| VIA93 | 1093 | 79/49 | Prospective | |
| VIA94 | 54981 | 79/86 | Prospective | |
| Widefield44 | 604 | 92/50 | Prospective | |
| Widefield46 | 111 | 97/70* | Prospective | |
| Widefield47 | 572 | 95/55 | Prospective | |
| Pilot Studies | Spectroscopy51 | 161 | 83/80 | Cross-Validation |
| Spectroscopy52 | 44 | 92/90 | Cross-Validation | |
| High Resolution29 | 28‡ | 100/100 | Prospective | |
| High Resolution66 | 38‡ | 100/91 | Retrospective | |
Visual Inspection with Acetic Acid (VIA)
*
The threshold for positive test result is LGD. For all others the threshold is HGD.
‡
N = # of biopsies and not the number of patients.