Effect of i.c.v. administration of TPI 1361-17 on MCH-induced food intake. Rats were administered vehicle (□, n = 10), or 2 nmole MCH (○, n = 9), or 2 nmole MCH and TPI 1361-17 (●, n= 9). TPI 1361-17 was tested at two doses: 1 nmole and 5 nmole. Experiments were performed one to two hours into the light cycle. Ten minutes after the administration, rats were given access to regular low fat-diet, food intake was monitored and cumulative food intake was calculated (Each data point expresses mean value with S.E.M. * P< 0.05; ANOVA/Bonferoni multiple comparison test for the effect of TPI 1361-17 + MCH versus MCH alone).