A, Effect of i.c.v. administration of TPI 1361-17 on non-ambulatory and ambulatory movements. Both movements were monitored for one hour after the administration of vehicle (○) or 5 nmole TPI 1361-17 (●); Sums of non-ambulatory and ambulatory movements (Each data point represents the value with the S.E.M.; n=10). B, Effect of TPI 1361-17 (10 nmole, i.c.v.) on conditioned taste aversion (□ water; ■ saccharin) (** P<0.01 vs. vehicle group, ANOVA/Dunnett’s multiple comparison test, n=6-8). Data expressed as mean ± SEM.