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. Author manuscript; available in PMC: 2009 Feb 1.
Published in final edited form as: Drug Discov Today Dis Models. 2008;5(1):45–57. doi: 10.1016/j.ddmod.2008.07.005

Fig. 4. Oscillatory activity mediated by elevated [K+]o.

Fig. 4

DC pulse (10 sec in duration, bar) was applied to the silent PY cell. Following high frequency firing, [K+]o increased and maintained oscillations in PY neuron after DC pulse was removed. (A) Single PY neuron. Insert shows typical burst of spikes. (B) Reciprocally connected PY-IN pair. Insert shows [K+]o evolution for PY neuron. Change of the [K+]o induced transition from slow (2–3 Hz) to fast (10–15 Hz) oscillations. Bursts of spikes (but not tonic spiking) in PY neuron induced spikes in the interneuron (see IN panel).