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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Mod Pathol. 2008 Sep 19;22(2):167–174. doi: 10.1038/modpathol.2008.146

Figure 3. Squamous and glandular components from a common premalignant lineage undergo divergent differentiation.

Figure 3

Identical PTEN mutation in the matched squamous and glandular elements of an EIN lesion was confirmed by immunodirected laser capture microdissection of DNA. A)PTEN-null glands and squamous morules of EIN have matched aberrantly migrating bands in a screening denaturing gradient electrophoresis gel (arrowheads) compared to PTEN expressing endometrial stroma. B)Direct sequencing confirms identical Exon 1 mutation 7∼9 del GCCinsTT, in squamous and glandular components.