Table 3. ANOVA analyses of plasma profiles among the pre-ARDS, ARDS and the Controla .
| Control | Pre-ARDS | ARDS | Mean (95% CI) ng/mlc | P b | |
| PI3 | 0.009 | ||||
| Control | NA | ++ | + | 80.3 (66.7–96.6) | |
| Pre-ARDS | NA | ++ | 87.5 (61.0–125.5) | ||
| ARDS | NA | 52.9 (42.7–65.6) | |||
| SLPI | 0.187 | ||||
| Control | NA | - | - | 139.4 (126.1–154.0) | |
| Pre-ARDS | NA | - | 125.2 (103.6–151.4) | ||
| ARDS | NA | 120.7 (107.6–135.5) | |||
| HNE | 0.012 | ||||
| Control | NA | + | ++ | 447.5 (380.6–526.2) | |
| Pre-ARDS | NA | - | 643.4 (472.8–875.7) | ||
| ARDS | NA | 633.0 (524.8–763.6) | |||
| HNE/PI3 | 0.0001 | ||||
| Control | NA | - | ++ | 5.6 (4.4–7.0) | |
| Pre-ARDS | NA | ++ | 7.5 (4.8–11.7) | ||
| ARDS | NA | 12.0 (9.2–15.6) |
ARDS, acute respiratory distress syndrome; PI3, neutrophil elastase inhibitor (elafin); SLPI, secretory leukocyte proteinase inhibitor; HNE, neutrophil elastase; 95%CI, 95% confidence interval.
a.
ANOVA analysis plasma profiles using general linear model with adjustment of covariates, including age, gender, type of lung injury, pre-admission steroid use, septic shock, and APACHE III score on ICU admission. Pairwise comparison: ++, P<0.05 after Bonferroni correction for multiple comparisons; +, P<0.05 without Bonferroni correction; -, P≥0.05; NA, not applicable.
b.
P values of general linear model for all groups.
c.
The unit of HNE/PI3 is fold change.