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. Author manuscript; available in PMC: 2010 Jan 16.
Published in final edited form as: Biochem Biophys Res Commun. 2008 Nov 21;378(3):473–477. doi: 10.1016/j.bbrc.2008.11.048

Figure 2. Analysis of GST-LRRK2 kinase activity in the presence of various inhibitors.

Figure 2

(A) Gö6976, (B) K-252a, (C) K252-b, (D) Raf-1 kinase inhibitor 1 and (E) Staurosporine are shown to be potent inhibitors of WT GST-LRRK2 using a range of concentration that was used to approximate the IC50. (F) G2019S GST-LRRK2 was also efficiently inhibited by these kinase inhibitors. The values correspond to the phosphorylation of LRRKtide in the presence of each inhibitor relative to reactions without inhibitors expressed as percent activity. (n=3, Error bars indicate standard error)