Table 1.

Affinity (K_m or K_i) of different class of β-lactamase enzymes for cefepime and other cephalosporins

Enzyme class	Km or Ki (μM)			Ref.
	Ceftazidime	Cefotaxime	Cefepime
β-lactamase
TEM-1	200	NR	650	[129]
SHV-1	500	NR	81	[129]
Extended-spectrum β-lactamases
TEM-3	100	26	190	[130]
TEM-12	130	94	130	[131]
TEM-24	180	25	90	[132]
TEM-26	10	13	105	[130]
TEM-121	150	430	40	[132]
SHV-5	9.2	5.0	100	[130]
SHV-18	47	8.7	81	[130]
CTX-M-3	>3000	113	170	[133]
CTX-M-10	NR	40	110	[130]
CTX-M-15	1760	54	1075	[133]
OXA-10	NR	NR	230	[129]
Carbapenemases
VIM-2	98	32	184	[134]
IMP-2	111	NR	7	[135]
KPC-2	230	NR	540	[129]
Ambler class C enzymes
AmpC Pseudomonas aeruginosa	8	NR	370	[129]
AmpC Morganella morganii	14	NR	690	[129]
AmpC Providencia stuartii	26	NR	780	[129]
AmpC Serratia marcescens	570	NR	>800	[129]
ADC-7	11.6	0.10	594	[20]
CMY-9	560	0.28	950	[136]
CMY-19	3.7	31	630	[136]
P99	15	NR	100	[137]

ADC: Acinetobacter-derived cephalosporinase; KPC: Klebsiella pneumoniae carbapenemases; NR: Not reported.