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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Expert Rev Anti Infect Ther. 2008 Dec;6(6):805–824. doi: 10.1586/14787210.6.6.805

Table 6.

Pharmacokinetic parameters of cefepime in healthy adults and patients with different renal insufficiency levels

Patient Dose (g) Administration Cmax (mg/l) Half-life (h) AUC (mg h/l) ClT (ml/min) ClR (ml/min) %Xu Ref.
Healthy adults 0.25 iv. 30 min 16.3 ± 2.4 1.9 ± 0.2 34 ± 3* 122 ± 10 96 ± 19 78.4 ± 11.3 [47]‡
Healthy adults 0.5 iv. 30 min 31.6 ± 2.9 1.8 ± 0.2 62 ± 6* 136 ± 13 116 ± 11 85.6 ± 2.9 [47]‡
Healthy adults 1 iv. 30 min 66.9 ± 4.6 1.9 ± 0.2 137 ± 9* 122 ± 8 103 ± 5 84.2 ± 2.2 [47]‡
Healthy adults 2 iv. 30 min 133 ± 35.5 1.8 ± 0.2 263 ± 33* 128 ± 16 104 ± 12 81.3 ± 6.9 [47]‡
Healthy adults 0.5 im. 13.9 ± 3.4 1.4 ± 0.9 60.0 ± 8.0 NR NR NR [156]§
Healthy adults 1 im. 29.6 ± 4.4 1.6 ± 0.4 137.0 ± 11.0 NR NR NR [156]§
Healthy adults 2 im. 57.5 ± 9.5 1.5 ± 0.4 262.0 ± 23.0 NR NR NR [156]§
Infected patients: ClCr > 100 ml/min 2 every 12 h iv. 30 min 259 ± 287 3.1 ± 2.6 734 ± 344 117 ± 72 NR NR [58]§
Infected patients: ClCr 60-100 ml/min 2 every 12 h iv. 30 min 167 ± 124 7.6 ± 5.2 1138 ± 540 73 ± 37 NR NR [58]§
Infected patients: ClCr < 60 ml/min 1-2 every 24 h iv. 30 min 207 ± 295 12.1 ± 6.3 845 ± 296 43 ± 18 NR NR [58]§
*

AUC0-∞.

‡

Data obtained after the 30-min infusion.

§

Data obtained at the steady state.

AUC24.

%Xu: Percentage of dose recovered in urine; ClR: Renal clearance; ClT: Total body clearance; im.: Intramusular administration; iv.: Intravenous administration; NR: Not reported.