Figure 1.

The molecular cascade that leads to the formation of amyloid fibrils. The formation of amyloid fibrils is a sequential process that proceeds from monomeric species into well-ordered amyloid fibrils. It is still unclear whether the formation of soluble oligomers such as the Aβ*56¹⁷ and the annular amyloid pores,⁸ is an on-pathway or an off-pathway process.