Table 2.
ORs and 95% CIs for the association between polymorphisms in CASR and colon cancer risk
| All colon cancer | Proximal colon cancer | Distal colon cancer | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Position/ Genotype | Controls N |
Cases N |
OR* | 95% CI | P for trend | Cases N |
OR* | 95%CI | P for trend | Cases N |
OR* | 95%CI | P for trend |
|
-465T>C (rs6678267) |
|||||||||||||
| CC | 1270 | 1039 | 1.00 | - | 505 | 1.00 | - | 508 | 1.00 | - | |||
| CT | 563 | 485 | 1.07 | 0.93-1.24 | 232 | 1.05 | 0.87-1.26 | 242 | 1.10 | 0.91-1.32 | |||
| TT | 87 | 56 | 0.80 | 0.57-1.13 | 0.93 | 26 | 0.75 | 0.48-1.18 | 0.69 | 28 | 0.83 | 0.54-1.29 | 0.82 |
| TT + CT vs. CC | 1.04 | 0.90-1.19 | 1.01 | 0.84-1.21 | 1.06 | 0.89-1.27 | |||||||
|
IVS1+2998A>G (rs672782) |
|||||||||||||
| GG | 778 | 643 | 1.00 | - | 311 | 1.00 | - | 315 | 1.00 | - | |||
| GA | 869 | 713 | 1.01 | 0.87-1.17 | 337 | 0.98 | 0.82-1.18 | 360 | 1.05 | 0.88-1.26 | |||
| AA | 272 | 219 | 0.98 | 0.80-1.21 | 0.93 | 110 | 1.02 | 0.79-1.32 | 0.97 | 103 | 0.94 | 0.72-1.23 | 0.88 |
| AA + GA vs. GG | 1.00 | 0.88-1.15 | 0.99 | 0.84-1.18 | 1.02 | 0.86-1.21 | |||||||
|
IVS1+12198G>A (rs6802749) |
|||||||||||||
| GG | 1329 | 1097 | 1.00 | - | 517 | 1.00 | - | 554 | 1.00 | - | |||
| GA | 544 | 444 | 1.00 | 0.86-1.16 | 224 | 1.07 | 0.88-1.28 | 207 | 0.93 | 0.77-1.12 | |||
| AA | 62 | 42 | 0.81 | 0.54-1.21 | 0.55 | 20 | 0.83 | 0.49-1.38 | 0.91 | 22 | 0.83 | 0.50-1.37 | 0.31 |
| AA + GA vs. GG | 0.98 | 0.85-1.13 | 1.04 | 0.87-1.25 | 0.92 | 0.76-1.10 | |||||||
|
IVS1+25086G>A (rs17203502) |
|||||||||||||
| GG | 526 | 431 | 1.00 | - | 218 | 1.00 | - | 204 | 1.00 | - | |||
| GA | 953 | 780 | 0.98 | 0.84-1.15 | 370 | 0.93 | 0.76-1.13 | 388 | 1.03 | 0.84-1.26 | |||
| AA | 461 | 382 | 0.99 | 0.82-1.20 | 0.92 | 180 | 0.93 | 0.73-1.17 | 0.51 | 194 | 1.05 | 0.83-1.33 | 0.68 |
| AA + GA vs. GG | 0.99 | 0.85-1.15 | 0.93 | 0.77-1.12 | 1.03 | 0.86-1.25 | |||||||
|
IVS1-18718C>A (rs1354162) |
|||||||||||||
| CC | 1530 | 1283 | 1.00 | - | 625 | 1.00 | - | 629 | 1.00 | - | |||
| CA | 338 | 267 | 0.95 | 0.79-1.13 | 122 | 0.89 | 0.71-1.12 | 137 | 0.99 | 0.79-1.23 | |||
| AA | 29 | 17 | 0.71 | 0.39-1.29 | 0.29 | 8 | 0.67 | 0.31-1.48 | 0.18 | 8 | 0.67 | 0.31-1.49 | 0.57 |
| AA + CA vs. CC | 0.93 | 0.78-1.10 | 0.87 | 0.70-1.09 | 0.96 | 0.78-1.20 | |||||||
|
IVS1-4705C>T (rs9875101) |
|||||||||||||
| CC | 957 | 784 | 1.00 | - | 371 | 1.00 | - | 395 | 1.00 | - | |||
| CT | 804 | 663 | 1.00 | 0.87-1.15 | 314 | 1.01 | 0.84-1.20 | 332 | 0.99 | 0.83-1.18 | |||
| TT | 178 | 143 | 0.97 | 0.77-1.24 | 0.89 | 82 | 1.19 | 0.89-1.59 | 0.37 | 57 | 0.77 | 0.56-1.06 | 0.25 |
| TT + CT vs. CC | 1.00 | 0.87-1.14 | 1.04 | 0.88-1.23 | 0.95 | 0.81-1.13 | |||||||
|
IVS1-160T>C (rs34178491) |
|||||||||||||
| TT | 1339 | 1121 | 1.00 | - | 535 | 1.00 | - | 560 | 1.00 | - | |||
| CT | 515 | 416 | 0.97 | 0.83-1.13 | 206 | 1.01 | 0.83-1.22 | 198 | 0.92 | 0.76-1.12 | |||
| CC | 58 | 40 | 0.83 | 0.55-1.25 | 0.42 | 21 | 0.91 | 0.55-1.52 | 0.88 | 19 | 0.79 | 0.47-1.35 | 0.27 |
| CC + CT vs. TT | 0.96 | 0.82-1.11 | 1.00 | 0.83-1.20 | 0.91 | 0.76-1.10 | |||||||
|
IVS3+298A>T rs3749204 |
|||||||||||||
| AA | 482 | 419 | 1.00 | - | 214 | 1.00 | - | 197 | 1.00 | - | |||
| AT | 930 | 765 | 0.97 | 0.82-1.14 | 354 | 0.87 | 0.71-1.07 | 393 | 1.06 | 0.87-1.31 | |||
| TT | 472 | 373 | 0.93 | 0.77-1.13 | 0.50 | 181 | 0.88 | 0.70-1.12 | 0.29 | 181 | 0.96 | 0.76-1.23 | 0.77 |
| TT + AT vs. AA | 0.96 | 0.82-1.11 | 0.88 | 0.72-1.06 | 1.03 | 0.85-1.25 | |||||||
|
IVS3+1048G>T (rs10934578) |
|||||||||||||
| GG | 907 | 731 | 1.00 | - | 344 | 1.00 | - | 365 | 1.00 | - | |||
| GT | 864 | 711 | 1.04 | 0.90-1.19 | 337 | 1.04 | 0.87-1.25 | 361 | 1.06 | 0.89-1.26 | |||
| TT | 169 | 152 | 1.13 | 0.89-1.44 | 0.33 | 86 | 1.35 | 1.01-1.81 | 0.09 | 62 | 0.93 | 0.67-1.27 | 0.98 |
| TT + GT vs. GG | 1.05 | 0.92-1.20 | 1.09 | 0.92-1.29 | 1.04 | 0.88-1.23 | |||||||
|
IVS3-685G>A (rs12485716) |
|||||||||||||
| GG | 955 | 799 | 1.00 | - | 411 | 1.00 | - | 372 | 1.00 | - | |||
| AG | 784 | 630 | 0.95 | 0.82-1.09 | 293 | 0.86 | 0.72-1.03 | 321 | 1.04 | 0.87-1.24 | |||
| AA | 173 | 148 | 0.98 | 0.77-1.25 | 0.61 | 58 | 0.75 | 0.54-1.04 | 0.03 | 85 | 1.20 | 0.90-1.61 | 0.27 |
| AA + AG vs. GG | 0.95 | 0.83-1.09 | 0.84 | 0.71-1.00 | 1.07 | 0.90-1.26 | |||||||
|
IVS4+2761C>T (rs35387386) |
|||||||||||||
| CC | 1823 | 1516 | 1.00 | - | 730 | 1.00 | - | 747 | 1.00 | - | |||
| CT | 104 | 64 | 0.73 | 0.53-1.00 | 30 | 0.71 | 0.47-1.08 | 34 | 0.78 | 0.52-1.16 | |||
| TT† | 1 | 1 | - | - | 0.06 | 1 | - | - | - | 0 | - | - | 0.18 |
| TT + CT vs. CC | 0.73 | 0.53-1.00 | 0.73 | 0.48-1.10 | 0.77 | 0.52-1.14 | |||||||
|
IVS4-1185C>T (rs35780274) |
|||||||||||||
| CC | 628 | 535 | 1.00 | - | 257 | 1.00 | - | 267 | 1.00 | - | |||
| CT | 917 | 732 | 0.96 | 0.82-1.12 | 340 | 0.92 | 0.76-1.12 | 369 | 0.97 | 0.80-1.17 | |||
| TT | 365 | 303 | 1.01 | 0.83-1.22 | 0.96 | 161 | 1.10 | 0.87-1.40 | 0.57 | 138 | 0.93 | 0.72-1.18 | 0.54 |
| TT + CT vs. CC | 0.97 | 0.84-1.12 | 0.97 | 0.81-1.17 | 0.96 | 0.80-1.15 | |||||||
|
IVS5-90C>T (rs4678174) |
|||||||||||||
| TT | 840 | 708 | 1.00 | - | 363 | 1.00 | - | 332 | 1.00 | - | |||
| CT | 865 | 670 | 0.90 | 0.78-1.04 | 314 | 0.83 | 0.69-0.99 | 335 | 0.97 | 0.81-1.16 | |||
| CC | 239 | 214 | 1.00 | 0.81-1.25 | 0.57 | 90 | 0.83 | 0.62-1.09 | 0.05 | 119 | 1.19 | 0.91-1.54 | 0.41 |
| CC + CT vs. TT | 0.92 | 0.81-1.06 | 0.83 | 0.70-0.98 | 1.01 | 0.85-1.20 | |||||||
|
IVS6+16T>C (rs2270916) |
|||||||||||||
| TT | 1425 | 1202 | 1.00 | - | 593 | 1.00 | - | 584 | 1.00 | - | |||
| CT | 476 | 365 | 0.94 | 0.80-1.10 | 169 | 0.87 | 0.71-1.07 | 183 | 0.97 | 0.80-1.19 | |||
| CC | 40 | 28 | 0.85 | 0.52-1.39 | 0.32 | 7 | 0.43 | 0.19-0.97 | 0.04 | 20 | 1.27 | 0.73-2.19 | 0.82 |
| CC + CT vs. TT | 0.93 | 0.80-1.08 | 0.84 | 0.69-1.02 | 1.00 | 0.82-1.21 | |||||||
|
Ex7+1224G>T A986S (rs1801725) |
|||||||||||||
| GG | 1476 | 1197 | 1.00 | - | 572 | 1.00 | - | 594 | 1.00 | - | |||
| GT | 430 | 371 | 1.08 | 0.92-1.26 | 182 | 1.10 | 0.90-1.34 | 181 | 1.06 | 0.87-1.30 | |||
| TT | 33 | 27 | 1.00 | 0.60-1.67 | 0.45 | 14 | 1.08 | 0.58-2.04 | 0.37 | 13 | 0.95 | 0.50-1.83 | 0.68 |
| TT + GT vs. GG | 1.07 | 0.92-1.25 | 1.10 | 0.91-1.33 | 1.05 | 0.87-1.28 | |||||||
|
Ex7+1236A>G R990G (rs1042636) |
|||||||||||||
| AA | 1640 | 1347 | 1.00 | - | 646 | 1.00 | - | 670 | 1.00 | - | |||
| GA | 262 | 224 | 1.04 | 0.86-1.27 | 112 | 1.09 | 0.85-1.38 | 106 | 1.00 | 0.78-1.27 | |||
| GG | 12 | 7 | 0.72 | 0.28-1.84 | 0.88 | 5 | 1.06 | 0.37-3.03 | 0.51 | 2 | 0.41 | 0.09-1.86 | 0.65 |
| GG + GA vs. AA | 1.03 | 0.85-1.25 | 1.09 | 0.86-1.37 | 0.97 | 0.76-1.24 | |||||||
|
Ex7+1299G>C E1011Q (rs1801726) |
|||||||||||||
| CC | 1725 | 1425 | 1.00 | - | 684 | 1.00 | - | 707 | 1.00 | - | |||
| CG | 180 | 149 | 0.97 | 0.77-1.22 | 77 | 1.06 | 0.80-1.41 | 68 | 0.88 | 0.66-1.19 | |||
| GG | 5 | 4 | 0.74 | 0.19-2.84 | 0.71 | 2 | 0.79 | 0.15-4.23 | 0.77 | 2 | 0.72 | 0.14-3.86 | 0.38 |
| GG + CG vs. CC | 0.97 | 0.77-1.21 | 1.05 | 0.80-1.40 | 0.88 | 0.66-1.18 | |||||||
| Global P | 0.52 | 0.10 | 0.93 | ||||||||||
*
Adjusted for age, race, sex and study center.
†
Only 1 case and control with TT genotype, thus estimates are not provided.