Table 3.

Association between CASR haplotypes and Colon Cancer among non-Hispanic whites

		All colon cancer			Proximal colon cancer			Distal colon cancer
Haplotype	Controls %	Cases %	OR*(95% CI)	p	Cases %	OR*(95% CI)	p	Cases %	OR*(95% CI)	p
Block 1(IVS1+12198G>A, IVS1+25086G>A, IVS1-18718C>A)†
G-A-C	37.8	37.7	1.00		37.2	1.00		38.4	1.00
G-G-C	34.7	35.2	1.02 (0.91-1.14)		35.5	1.04 (0.90-1.21)		34.8	0.99 (0.86-1.15)
A-G-C	16.3	16.3	1.00 (0.87-1.16)		17.0	1.06 (0.88-1.27)		15.6	0.94 (0.79-1.14)
G-A-A	10.3	10.0	0.96 (0.81-1.15)		9.3	0.91 (0.73-1.14)		10.4	0.99 (0.80-1.23)
Global P				0.64			0.83			0.97
Block 2(IVS3+298A>T, IVS3+1048G>T)‡
T-G	50.3	49.6	1.00		48.7	1.00		50.2	1.00
A-T	31.2	32.2	1.04 (0.93-1.16)		33.7	1.11 (0.97-1.28)		31.0	0.98 (0.85-1.14)
A-G	18.4	18.1	1.00 (0.87-1.14)		17.5	0.98 (0.83-1.16)		18.6	1.01 (0.85-1.19)
Global P				0.89			0.42			0.97
Block 3(IVS5-90T>C, IVS6+16T>C)§
T-T	66.6	67.7	1.00		70.1	1.00		65.8	1.00
C-T	18.6	18.4	0.98 (0.86-1.11)		17.5	0.90 (0.76-1.05)		19.3	1.05 (0.89-1.23)
C-C	14.7	13.8	0.93 (0.81-1.07)		12.4	0.80 (0.67-0.97)		14.9	1.04 (0.87-1.23)
Global P				0.48			0.08			0.79

^*Adjusted for age, sex, and study center.

^†Loci of SNPs included in block are in the following order: rs6802749, rs17203502, and rs1354162.

^‡Loci of SNPs included in block are in the following order: rs3749204, rs10934578.

^§Loci of SNPs included in block are in the following order: rs4678174, rs2270916.