Table 10.
Sex Differences (Sample number used for QPCR, Female n= 11; Male n=8) | ||||||
---|---|---|---|---|---|---|
AccessioN No. | GeneID | Fold Changes (M/F) | Gene Name | |||
Microarray | p Value | Q-PCR | p Value | |||
NR_001564 | XIST | −124.03 | 0.00 | −106.0 | 0.00 | X (inactive)-specific transcript |
NM_004660 | DDX3Y | 16.17 | 0.00 | 40.0 | 0.00 | DEADH (Asp-Glu-Ala-AspHis) box polypeptide, Y chromosome |
BC033974 | ZFY | 6.79 | 0.00 | 15.0 | 0.00 | Zinc finger protein, Y-linked |
AF332225 | CYorf15B | 15.48 | 0.00 | 22.0 | 0.00 | Chromosome Y open reading frame 15B |
Differences due to aging (Sample number used for QPCR, Young n = 8; Old n = 8) | ||||||
Accession No. | GeneID | Fold Changes (O/Y) | Gene Name | |||
Microarray | p Value | Q-PCR | p Value | |||
BC002704 | STAT1 | −3.3 | 0.035 | −1.51 | 0.03 | Signal transducer and activator of transcription 1 |
NM_001565 | CXCL10 | −8.37 | 0.041 | −1.96 | 0.05 | Small inducible cytokine subfamily B (Cys-X-Cys), member 10 |
NM_002122 | HLA-DQA1 | −3.5 | 0.035 | −1.57 | 0.05 | Histocompatibility complex, class II, DQ alpha 1 |
NM_152679 | SLC10A4* | 4.41 | 0.032 | 2.00 | 0.05 | Solute carrier family 10 (sodium/bile acid cotransporter family), member 4 |
NM_138455 | CTHRC1* | 2.82 | 0.047 | 1.81 | 0.05 | Collagen triple helix repeat containing 1 |
AI500293 | CHRM1* | −1.61 | 0 | −1.28 | 0.04 | Cholinergic receptor, muscarinic 1 |
Tested with mixed population of male and female young and old subjects