Table 2.
Gene expression ratio of older (65, 65 and 69 years) to younger (19, 25 and 38 years) (O/Y) female parotid glands*
| Gene Name | Acc. No. | Gene ID | Ratio (O/Y) | Direction | Ontology |
|---|---|---|---|---|---|
| Cytokine subfamily B (Cys-X-Cys), member 10 | NM_001565 | CXCL10 | 8.37 | Down | Chemokine |
| Solute carrier family 10 member 4 | AI421796 | SLC10A4 | 4.41 | Up | Ion transport |
| Diubiquitin D | NM_006398 | UBD | 3.89 | Down | Proteolysis |
| Histocompatibility complex, class II, DQ alpha 1 | BG397856 | HLA-DQA1 | 3.5 | Down | Antigen processing |
| Interferon, alpha-inducible protein | NM_022873 | IFI6 | 3.49 | Down | Release of cytochrome c from mitochondria |
| Short-chain alcohol dehydrogenase family member | NM_005794 | DHRS2 | 3.38 | Up | Electron transport |
| Interferon-stimulated transcription factor 3, gamma | NM_006084 | ISGF3G | 3.34 | Down | Regulation of transcription |
| Signal transducer and activator of transcription 1, 91kDa | BC002704 | STAT1 | 3.31 | Down | Regulation of transcription |
| Interferon-stimulated protein, 15 kDa | NM_005101 | ISG15 | 3.05 | Down | Response to other organism |
| Ependymin related protein 1 | BC000686 | EPDR1 | 3 | Up | Ion binding |
| Cysteine/tyrosine-rich 1 | H06649 | CYYR1 | 2.92 | Up | |
| Periostin, osteoblast specific factor | D13665 | POSTN | 2.86 | Up | Skeletal development |
| Collagen triple helix repeat containing 1 | AA584310 | CTHRC1 | 2.82 | Up | Phosphate transport |
| Histone deacetylase 9 | BM726008 | HDAC9 | 2.73 | Up | Negative regulation of transcription |
| Phosphodiesterase 5A, cGMP-specific | BF221547 | PDE5A | 2.68 | Up | Signal transduction |
| Immunoglobulin heavy constant gamma 1 | BC001872 | IGHG1 | 2.66 | Down | Antigen processing |
| Stearoyl-CoA desaturase | AA678241 | SCD | 2.49 | Down | Lipid metabolic process |
| Rho GTPase activating protein 6 | NM_001174 | ARHGAP6 | 2.4 | Up | Regulation of catalytic activity |
| Glycoprotein (transmembrane) nmb (GPNMB) | NM_002510 | GPNMB | 2.37 | Up | Negative regulation of cellular process |
| Interferon regulatory factor 7 | NM_004030 | IRF7 | 2.36 | Down | Negative regulation of transcription |
| Four and a half LIM domains 1 | AF063002 | FHL1 | 2.31 | Up | Metal Binding |
| Lysosomal associated protein transmembrane 4 beta | AW149681 | LAPTM4B | 2.31 | Up | Transport |
| Cytochrome P450, family 4, subfamily B, polypeptide 1 | J02871 | CYP4B1 | 2.26 | Up | Electron transport |
| Frizzled-related protein | U91903 | FRZB | 2.23 | Up | Cell communication |
| Four and a half LIM domains 1 (FHL1) | NM_001449 | FHL1 | 2.18 | Up | Metal Binding |
| Solute carrier family 1 , member 1 | AW235061 | SLC1A1 | 2.16 | Up | Transport |
| Epithelial stromal interaction 1 | AA781795 | EPSTI1 | 2.15 | Down | |
| Guanylate binding protein 1, interferon-inducible | AW014593 | GBP1 | 2.15 | Down | Immune response |
| Tubulin tyrosine ligase-like family, member 7 | NM_024686 | TTLL7 | 2.14 | Up | Protein modification |
| NGFRAP1-like 1 | AV726956 | NGFRAP1L1 | 2.13 | Down | |
| Fatty acid synthase | AI954041 | FASN | 2.12 | Down | Fatty acid biosynthetic process |
| Guanylate binding protein 1, interferon-inducible | BC002666 | GBP1 | 2.1 | Down | Immune response |
| Interferon induced transmembrane protein 3 (1-8U) | BF338947 | IFITM3 | 2.1 | Down | Immune response |
| Asparaginase like 1 | NM_025080 | ASRGL1 | 2.09 | Up | Glycoprotein catabolic process |
| Myxovirus (influenza virus) resistance 2 | NM_002463 | MX2 | 2.09 | Down | Defense response |
| Solute carrier organic anion transporter, member 1A2 | NM_021094 | SLCO1A2 | 2.09 | Up | Transport |
| Interferon induced transmembrane protein 1 | AA749101 | IFITM1 | 2.08 | Down | Immune response |
| Plasminogen activator, tissue | NM_000930 | PLAT | 2.07 | Up | Protein modification |
| Solute carrier family 25, member 34 | AU151211 | SLC25A34 | 2.07 | Up | Transport |
| ATP-binding cassette, member 2 (ABCB2) | NM_000593 | TAP1 | 2.03 | Down | Response to stimulus |
| Low density lipoprotein receptor | NM_000527 | LDLR | 2.03 | Down | Protein Biosysnthesis |
| Cysteine/tyrosine-rich 1 | AI458003 | CYYR1 | 2.02 | Up | |
| NLR family, CARD domain containing 5 | AA005023 | NLRC5 | 2.02 | Down | Defense response |
| Lysosomal associated protein transmembrane 4 beta | NM_018407 | LAPTM4B | 2.01 | Up | Transport |
| Monocyte to macrophage differentiation-associated | NM_012329 | MMD | 2.01 | Up | Cytolysis |
| Peroxisomal biogenesis factor 6 | NM_000287 | PEX6 | 2.01 | Down | Peroxisome organization |
| Integrin beta 1 binding protein 1 | NM_004763 | ITGB1BP1 | 2 | Up | Cell adhesion |
*
Genes listed had signal intensity of >5.0 in at least one group, expression ratio of >2.0 (between glands), p value <0.05, with known gene identity.