Table 6.
Gender related differential gene expression in human parotid gland*
| Higher Expression in Female | ||||
|---|---|---|---|---|
| Gene Name | Accession No. | Gene ID | Ratio | Ontology |
| X (inactive)-specific transcript | NR_001564 | XIST | 124.03 | |
| Zinc finger, CCHC domain containing 2 | NM_017742 | ZCCHC2 | 3.52 | Metal Ion Binding |
| Pinin, desmosome associated protein | NM_002687 | PNN | 3.03 | Transcription regulation |
| Hemoglobin, alpha1 | NM_000517 | HBA1 | 3.01 | Oxygen transport |
| PRO1073 protein | NM_014086 | PRO1073 | 2.62 | Unknown |
| Serpin peptidase inhibitor clade B (ovalbumin), member 9 | BC002538 | SERPINB9 | 2.59 | Anti-apoptosis signal transduction |
| Collagen, type VI, alpha 2 | NM_001849 | COL6A2 | 2.53 | Organization and biogenesis |
| Family with sequence similarity 108 member 1 | NM_031213 | FAM108A1 | 2.49 | Hydrolase activity |
| WW, C2 and coiled-coil domain containing 1 | NM_015238 | WWC1 | 2.46 | Cellular function |
| ADP-ribosylation factor 3 | NM_001659 | ARF3 | 2.45 | GTPase signal transduction |
| ATPase, Class V, type 10C | NM_024490 | ATP10A | 2.45 | Cation transport |
| Immunoglobulin heavy constant mu | BC001872 | IGHG1 | 2.43 | Immune response |
| Immediate early response 3 interacting protein 1 | NM_016097 | IER3IP1 | 2.33 | Integral to membrane |
| ATP-binding cassette (CFTR/MRP), member 10 | NM_033450 | ABCC10 | 2.3 | Transport |
| Rabaptin, RAB GTPase binding effector protein 2 | NM_024816 | RABEP2 | 2.27 | Endocytosis, protein transport |
| Essential meiotic endonuclease 1 homolog 1 | NM_152463 | EME1 | 2.27 | DNA repair |
| Misshapen-like kinase 1(zebrafish) (MINK1 | NM_015716 | MINK1 | 2.26 | Protein Phosphorylation |
| Arachidonate 5-lipoxygenase | NM_000698 | ALOX5 | 2.25 | Linoleic acid metabolism |
| Secreted phosphoprotein 1 | NM_001040058 | SPP1 | 2.18 | TGF Beta Signaling Pathway |
| Small nuclear ribonucleoprotein polypeptide A | NM_004596 | SNRPA | 2.16 | mRNA processing |
| Member RAS oncogene family | NM_021168 | RAB40C | 2.15 | GTPase signal transduction |
| RUN and TBC1 domain containing 1 | BC029251 | RUTBC1 | 2.13 | Unknown |
| Protease, serine, 21 | NM_006799 | PRSS21 | 2.13 | Proteolysis |
| Additional sex combs like 1 | NM_015338 | ASXL1 | 2.1 | Transcription regulation |
| Insulin-like growth factor 2 mRNA binding protein 2 | NM_006548 | IGF2BP2 | 2.08 | Protein biosynthesis |
| Zinc finger protein 432 | NM_014650 | ZNF432 | 2.07 | Transcription regulation |
| Metastasis associated lung adenocarcinoma transcript 1 | NR_002819 | MALAT1 | 2.07 | Binding |
| UDP-N-acetyl-alpha-D-galactosamine: Polypeptide N-acetylgalactosaminyltransferase-like 1 | AI097463 | GALNTL1 | 2 | Glycan biosynthesis |
| Higher Expression in Male | ||||
|---|---|---|---|---|
| Gene Name | Accession No. | Gene ID | Ratio | Ontology |
| Ribosomal protein S4, Y-linked (RPS4Y) | NM_001008 | RPS4Y1 | 29.65 | Protein Biosysnthesis |
| DEADH (Asp-Glu-Ala-AspHis) box polypeptide, Y linked | NM_004660 | DDX3Y | 16.17 | Nucleotide binding |
| Chromosome Y open reading frame 15A, Testis protein | AF332224 | CYorf15A | 15.48 | |
| Eukaryotic translation initiation factor 1A, Y-linked | BC005248 | EIF1AY | 14.74 | Protein Biosysnthesis |
| Smcy homolog, Y-linked | NM_004653 | SMCY | 11.81 | Transcription regulation |
| Zinc finger protein, Y-linked | NM_003411 | ZFY | 6.79 | Transcription regulation |
| Ubiquitin specific peptidase 9, Y-linked | NM_004654 | USP9Y | 5.28 | Ubiquitin-dependent protein catabolism |
| Lumican | NM_002345 | LUM | 2.82 | visual perception, Collagen fibril organization |
| Cofilin 1(non-muscle) | NM_005507 | CFL1 | 2.63 | Signal Transduction |
| SH3 domain binding glutamic acid-rich protein like | NM_003022 | SH3BGRL | 2.61 | SH3/SH2 adaptor activity |
| Cysteine-rich secretory protein 2 | NM_003296 | CRISP2 | 2.51 | Testis Specific |
| Acid phosphatase, testicular | NM_033068 | ACPT | 2.43 | Riboflavin metabolism |
| RNA binding motif protein 3 | NM_006743 | RBM3 | 2.33 | RNA Processing |
| Rho GTPase activating protein 5 | NM_001173 | ARHGAP5 | 2.24 | GTPase mediated signal transduction |
| Inhibin beta A | NM_002192 | INHBA | 2.22 | TGF Beta Signaling Pathway |
| Short coiled-coil protein | NM_032547 | SCOC | 2.18 | Unknown |
| Crystallin, beta B2 | NM_000496 | CRYBB2 | 2.16 | Visual perception |
| Apolipoprotein D | NM_001647 | APOD | 2.15 | Lipid metabolism |
| Similar to ubiquitin B precursor | NM_018955 | UBB | 2.13 | Protein ubiquitination |
| HBS1-like | NM_006620 | HBS1L | 2.12 | Protein Biosynthesis |
| Replication protein A3 | NM_002947 | RPA3 | 2.11 | DNA replication |
| Chromosome 1 open reading frame 43 | NM_015449 | C1orf43 | 2.11 | Unknown |
| Cysteine/tyrosine-rich 1 | NM_052954 | CYYR1 | 2.1 | Unknown |
| Basic helix-loop-helix domain containing, class B, 2 | NM_003670 | BHLHB2 | 2.08 | Transcription regulation |
| Chromosome 1 open reading frame 80 | NM_022831 | C1orf80 | 2.06 | Unknown |
| Fatty acid binding protein 7 | NM_001446 | FABP7 | 2.05 | Fatty acid metabolism |
| Ras-related C3 botulinum toxin substrate 1 | NM_006908 | RAC1 | 2.04 | GTPase mediated signal transduction |
*
Genes listed had a signal intensity of >5.0 in at least one group, expression ratio of >2.0 (between glands), p value <0.05, with known gene identity.