Figure 4. CCR1-deficiency does not alter extent of renal dysfunction after ischemia-reperfusion injury.
A, Histopathologic analysis. PAS-stained outer medulla of the left (injured) kidney is shown for wild type (Ai, iii, v, vii, ix) and CCR1-deficient (Aii, iv, vi, viii) mice at the times after ischemia-reperfusion injury indicated to the left of each panel (Ai-viii) or 24 hours after sham operation (ix). Scale bar indicates 50µm. B–E, Quantitation of the indicated measures of renal damage post-IR. sham, sham-operated wild type mice tested 24 hours after surgery. Values are mean ± SEM and are from 3 independent experiments with 3–5 animals for each condition in each experiment.