Table 3.
Linkage peaks with maximum LOD scores larger than 3, and markers under the peaks with LOD scores larger than 3.
| Peak Region |
Marker | Pos* (cM) |
LOD w/o interaction AA†/ca‡ |
LOD w/ interaction AA/CA |
Cross-validation |
|---|---|---|---|---|---|
| 1p36 | D1S468 D1S1612 D1S1597 |
4.22 16.22 29.93 |
0.9/0.0 0.5/0.0 0.2/0.0 |
4.6/1.8 4.1/1.3 3.3/0.9 |
LOD=3.9 centered at TNFRSF1B gene in Anglo-Celtic Caucasians with hypertension status trait 22; LOD=3.5 at D1S2672 in French Canadians with hypertension status trait 23; LOD=2.8 at D1S468 in Australians with hypertension status trait 24 |
| 1q31 | D1S518 D1S1660 |
202.19 212.44 |
0.1/0.0 2.1/0.0 |
3.2/0.0 3.6/0.0 |
LOD=2.8 at 192 cM in Caucasians with hypertension status trait25; LOD=2.34 at 203 cM in Mexican Americans with mean arterial BP trait26 |
| 2p24-p25 | D2S1400 D2S1360 |
27.6 38.33 |
1.8/0.0 2.2/0.0 |
3.5/1.0 3.7/0.9 |
LOD=3.02 at 27 cM in Talana population with hypertension status trait30 |
| 3p14 | D3S4542 D3S2329 |
89.91 91.18 |
0.0/0.7 0.0/0.9 |
0.0/3.1 0.0/3.3 |
p value=0.0001 at 88.6-117.8 cM in Caucasians using meta analysis31 |
| 4q21 | D4S2361 | 93.48 | 0.0/1.3 | 0.0/3.5 | Z score=3.2 at 95-132 cM in Caucasians with SBP trait28 |
| 4q35 | D4S408 | 195.06 | 0.1/0.0 | 3.3/0.0 | |
| 5p13 | D5S1470 | 45.34 | 0.7/0.0 | 3.2/1.1 | LOD=2.03 at 53 cM in Caucasians with pulse pressure trait32 |
| 6p23 | D6S2434 | 25.08 | 0.1/0.0 | 3.0/0.0 | |
| 7p21 | D7S513 | 17.74 | 0.0/1.7 | 0.0/3.2 | |
| 7q11 | D7S3046 | 78.65 | 0.1/0.1 | 3.7/3.6 | LOD=2.42 at 71 cM in Caucasians with pulse pressure trait32 |
| 8p21-p22 | D8S1145§ D8S136§ |
37.04 43.96 |
0.0/1.2 0.0/1.9 |
2.4/3.1 0.0/3.0 |
LOD=1.8 at the same marker in Dutch families with DBP trait33 p value=0.0002 at 42.9 cM in Taiwanese families with SBP trait34 |
| 9q12 | D9S301§ | 66.32 | 0.0/1.7 | 2.3/3.3 | |
| 9q21 | D9S1122 D9S922 |
75.88 80.31 |
0.0/0.8 0.0/1.1 |
0.0/3.1 0.0/3.3 |
|
| 10p11 | D10S1208 | 63.3 | 0.2/0.0 | 3.0/0.0 | |
| 10q26 | D10S1248 | 165.27 | 1.2/0.0 | 3.4/0.0 | |
| 12p12-p13 | D12S373§ D12S372 |
36.06 6.42 |
0.0/0.5 1.0/0.0 |
3.3∥/1.6 3.7/0.0 |
LOD=3.44 at 40 cM in Chinese population with hypertension status trait35 |
| 13q13-q14 | D13S1493 D13S894 D13S325 D13S788 |
25.8 32.9 38.96 45.55 |
0.2/0.6 0.5/0.7 0.4/0.9 0.0/1.9 |
0.0/3.2 3.0/4.2 1.7/3.8 0.0/4.5 |
|
| 13q33 | D13S779 | 82.93 | 0.0/1.0 | 0.0/3.5 | |
| 14q24 | D14S588 | 75.61 | 0.0/0.7 | 0.0/3.0 | |
| 14q31 | D14S606 D14S617 |
91.62 105.53 |
0.0/0.3 0.0/0.7 |
0.0/3.3 0.0/3.5 |
LOD=2 at 100 cM in Chinese and Japanese Americans with hypertension trait36; LOD=3.0 at 106 cM in combined European American and African American sample with pulse pressure trait37 |
| 15q13-q14 | D15S165 ACTA |
20.24 31.46 |
0.2/1.0 0.1/1.1 |
3.0/1.9 3.1/1.7 |
|
| 15q22-q25 | D15S1507 D15S655 |
60.17 82.84 |
0.1/1.5 0.0/0.3 |
2.8/3.5 3.1/0.7 |
p value=0.0033 at 97 cM in Caucasians with SBP trait38 |
| 16p11 | D16S753 | 57.79 | 0.0/0.8 | 0.0/3.5 | LOD=2.73 at 52 cM in Mexican Americans with trait as longitudinal change in SBP26; LOD=2.74 at 64 cM in Chinese population with SBP trait27; Z score=3.2 at 40-62 cM in Caucasians with SBP trait28 |
| 19p13 | D19S714 | 42.28 | 0.2/0.0 | 3.4/0.8 | LOD=2.14 at 48.5 cM in African Americans with SBP trait39; LOD=2.39 at 47 cM in Nigerians with SBP trait40 |
| 21q22 | D21S1440 D21S2055 |
36.77 40.49 |
0.7/0.2 1.0/0.0 |
3.4/1.6 3.2/0.0 |
LOD=2.82 at the same marker in Mexican Americans with SBP trait41 |
| 22q12 | D22S689§ | 28.57 | 0.0/0.0 | 3.3∥/0.0 | LOD=2.07 at 32.4 cM in Finlander with hypertension status trait42 |
*
Positions are based on the Marshfield map
†
AA: African Americans
‡
CA: Caucasians
§
LOD scores of this marker are for DBP phenotype, others are for SBP
∥
maximum likelihood estimate converges at the boundary of parameter space.