Table 2.

Palladium-Catalyzed Carboamination of N-Protected γ–Aminoalkenes with Functionalized Aryl Bromides^a

Entry	Amine	Aryl bromide	Product	Rxn. Time (h)	Yield (%) b
1				15 11	75 (77) c,e
2	1			27 26	82 (81) c,e
3	1			20	78 d
4	1			18	76 d
5	1			28	71
6				18 15	79 (72) c,e
7	3			18	76 d,f
8				16 18	88 (17)c
9	4			18	88 d

^aConditions: 1.0 equiv amine, 1.2 equiv ArBr, 2.3 equiv Cs₂CO₃, 2 mol % Pd(OAc)₂, 4 mol % Dpe-phos, dioxane (0.2–0.25 M), 100–105 °C.

^bYield refers to average isolated yield obtained in two or more experiments.

^cNaO tBu was used in place of Cs₂CO₃ and toluene was used as solvent.

^dThe reaction was conducted at 85 °C in DME solvent.

^ePd₂(dba)₃ was used in place of Pd(OAc)₂.

^fDppe was used in place of Dpe-phos.