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. Author manuscript; available in PMC: 2009 Sep 2.
Published in final edited form as: J Am Coll Cardiol. 2008 Jul 2;52(10):869–881. doi: 10.1016/j.jacc.2008.04.055

Figure 5. Pioglitazone induces IκBα protein expression in vivo in a PPARα dependent manner.

Figure 5

PPARα+/+ (A) and PPARα−/− (B) mice were treated with pioglitazone (20mg/kg, 7 days via gavage) before livers were harvested and total protein extracted for Western blot analysis of IκBα and GAPDH protein levels. Each lane represents a single mouse. (C) The effects of pioglitazone (black bars) and vehicle (white bars) on IκBα protein expression were quantified and normalized to GAPDH expression. Mean values SD are shown (n = 4 mice/group. *p<0.05 pioglitazone vs. vehicle, Mann-Whitney test).