Table 1.
Correlation between neuropilin expression and tumor progression
| Tumor Type | NRP1 | NRP2 | Status | Reference |
| Glioma | ↑ | n.a.1 | Poorer prognosis | 42 |
| Acute myeloid leukemia | ↑ | n.a. | Poorer survival | 43 |
| Colon cancer | ↑ | n.a. | Poorer survival, higher lymph node and liver metastasis | 44 |
| Gastrointestinal cancer | ↑ | n.a. | Higher invasiveness | 45 |
| Osteosarcoma | n.a. | ↑ | Increased vascularity, poorer prognosis | 46 |
| Ovarian carcinoma | ↑ | ↑ | Poorer prognosis; high VEGF/SEMA ratio is prognostic for poor survival | 36 |
| Nonsmall cell lung carcinoma (NSCLC) | ↑ | ↑ | Poorer prognosis; increased vascularity | 47 |
| Nonsmall cell lung carcinoma (NSCLC) | ↑ | ↑ | NRP1, NRP2, and VEGF165 increase with tumor stage; loss of SEMA3F in premalignant lesions | 48 |
| Colon cancer | ↓ | n.c.2 | Poorer prognosis | 49 |
n.a.1:
not analyzed;
n.c.2:
no change.