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Polarity systems in motile cells. Polarity can be described from the perspective of the antagonistic activity of the PI3K/PTEN system, as described for Dictyostelium orientation, the Rac/RhoA system, as described in neutrophils, the Par/Scribble system, as described in T cells, and the segregation of L- and U-rafts, as described in T cells and neutrophils. The interrelationships between these four systems are not well defined. See the text for details.
