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. 2008 Jul-Sep;2(3):208–213. doi: 10.4161/cam.2.3.6353

Figure 3.

Figure 3

Structures of representative armed oncolytic HSV-1. The HSV-1 genome consists of long and short unique regions (UL and US) each bounded by terminal (T) and internal (I) repeat regions (RL and RS). Armed oncolytic HSV-1 created by using the T-BAC (or G47Δ-BAC) system has the backbone structure of G47Δ, a third-generation oncolytic HSV-1. It has triple deletions in the γ34.5, ICP6 and α47 genes. The transgene is inserted into the deleted ICP6 locus. As a marker, it also expresses the LacZ gene driven by the ICP6 promoter. Armed oncolytic HSV-1 created by using the HSVQuik system has the backbone structure similar to G207 or MGH1, second-generation oncolytic HSV-1. It has double deletions in the γ34.5 and ICP6 genes. The transgene is inserted into the deleted ICP6 locus. As a marker, it also expresses the GFP gene driven by the ICP6 promoter. The OncoVEX series has the backbone structure of a second-generation oncolytic HSV-1 with double deletions in the γ34.5 and α47 genes. The transgene is inserted into the deleted γ34.5 loci.