Table 4.
Storage condition | Concentration (ng/mL) | Stability (%) | CV (%) | Replicates | |
---|---|---|---|---|---|
ABT-888 | |||||
Stock solution 4 h Ambient temp. |
1,000,000 | 101.8 | 4.0 | 3 | |
Stock solution 3 months 4 °C |
1,000,000 | 104.9 | 2.9 | 3 | |
Plasma 4 h Ambient temp. |
QCL | 20 | 106.5 | 6.7 | 3 |
QCM | 200 | 95.7 | 7.0 | 3 | |
QCH | 800 | 101.9 | 7.5 | 3 | |
Plasma 3 freeze-thaw cycles −80 °C |
QCL | 20 | 102.1 | 2.5 | 3 |
QCM | 200 | 98.9 | 4.9 | 3 | |
QCH | 800 | 100.0 | 4.4 | 3 | |
Plasma 3 months −80 °C |
QCL | 20 | 113.9 | 4.3 | 3 |
QCM | 200 | 98.2 | 6.2 | 3 | |
QCH | 800 | 98.5 | 4.2 | 3 | |
M8 | |||||
Stock solution 4 h Ambient temp. |
1,000,000 | 101.0 | 3.5 | 3 | |
Stock solution 3 months 4 °C |
1,000,000 | 98.2 | 5.8 | 3 | |
Plasma 4 h Ambient temp. |
QCL | 20 | 105.0 | 12.5 | 3 |
QCM | 200 | 94.4 | 8.1 | 3 | |
QCH | 800 | 99.9 | 6.6 | 3 | |
Plasma 3 freeze-thaw cycles −80 °C |
QCL | 20 | 102.8 | 13.9 | 3 |
QCM | 200 | 94.4 | 5.1 | 3 | |
QCH | 800 | 96.8 | 4.3 | 3 | |
Plasma 3 months −80 °C |
QCL | 20 | 90.5 | 15.6 | 3 |
QCM | 200 | 92.7 | 12.2 | 3 | |
QCH | 800 | 89.2 | 9.8 | 3 |